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From baby mice to designer humans?

Ethicists warn about the moral and legal implications of creating eggs from other cells in the body


Scientists in Japan are growing mice from skin cells.

A team of researchers at Kyushu University last year converted tail cells from adult female mice into viable eggs, and then inseminated those eggs to produce embryos. They implanted the embryos in female mice who gave birth to healthy baby mice.

The process, called in vitro gametogenesis (IVG), is a big leap from today’s in vitro fertilization (IVF). With IVG, doctors can artificially create eggs and sperm by coaxing cells from other parts of the body into stem cells, and then into eggs and sperm.

Researchers say it is only a matter of time before they can use the process for human reproduction.

But experts warn of serious ethical, medical, and legal consequences for using this new technology on humans. In a cautionary article published earlier this year in the journal Science Translational Medicine, a group of academics from Harvard and Brown universities noted the technology “promises to transform the fields of reproductive and regenerative medicine,” but also creates “vast ethical and social policy challenges” that must be addressed.

With IVG, creating life no longer would require a man and a woman: Two men could make a baby biologically related to them both using the skin cells of one to make an egg, and the sperm of the other. A woman could make a baby by herself using her cell-turned-sperm and her egg, almost like cloning. A group of three or four people could create a baby by creating two embryos, and then taking an egg from one and a sperm from the other, creating another embryo with multiple parents. Such scenarios inevitably would affect the traditional understanding of parenting.

The article also addressed the potential for “unauthorized” use of biomaterials, or what others have called the “Brad Pitt scenario:” Someone retrieves a skin cell from a hotel room bed or bathroom, creating a baby biologically related to someone without their knowledge.

“Should the law criminalize such an action? If it takes place, should the law consider the source of the skin cells to be a legal parent to the child, or should it distinguish an individual’s genetic and legal parentage?” the authors wrote.

They also raised the potential for bioethical issues on a massive scale.

“IVG may raise the specter of ‘embryo farming’ on a scale currently unimagined, which might exacerbate concerns about the devaluation of human life,” wrote the authors, pointing to the inevitable destruction of large numbers of embryos, the commercialization of egg production, the creation of an “all but inexhaustible supply” of embryonic stem cells for research, and the open invitation for a couple to create “designer babies” due to limitless eggs.

But significant scientific hurdles remain.

“People are a lot more complicated than mice,” Susan Solomon, chief executive of the New York Stem Cell Foundation, told The New York Times. “And we’ve often seen that the closer you get to something, the more obstacles you discover.”

Despite those hurdles, the article’s authors warn IVG technology is moving faster than our conversations about the ethical questions it raises.

“We have come to realize that scientific developments are outpacing our ability to think through them,” Eli Y. Adashi, a medical science professor at Brown, told The New York Times. “It’s a challenge for which we are not fully prepared.”

Human history rewrite?

Paleoanthropologists declare they have rewritten human history with the discovery of two fossils that supposedly show humans split first from the apes in Europe, rather than Africa, as scientists previously believed. An international team of researchers found the two fossils, a jawbone and a tooth, in Bulgaria and Greece. Those fragments come from an “ape-like creature” classified as a so-called “missing link,” the last common ancestor of both chimpanzees and humans. They believe it is several hundred thousand years older than what was believed to be the oldest known hominid, found in Chad. Much of the team’s conclusions came from studying the root structures of the fossilized tooth, which are more similar to those found in humans than apes. But Jonathan Wells, a biologist and fossil expert at the Discovery Institute, notes fossil finds never provide the direct link between apes and humans that evolutionists yearn for. And in some cases, much-hyped fossil finds turn out to be something else entirely, as in the case of the 2009 ancestor of modern primates that turned out to be a lemur. —Leigh Jones​

What's so special about flamingos

Don’t flamingos get tired standing on one leg all the time? A pair of scientists in Georgia devoted hours to studying why those zany pink birds prefer balancing on one foot for so long when it would make a human sore and stiff. Turns out, flamingo legs are uniquely designed to stay steady with minimal effort when their bodies are aligned over just one foot. Standing on two legs makes them wobble and takes more energy. Flamingos so far are the only birds in which this unique joint structure, which appears to be stabilized by their body weight, has been observed. The study required the scientists to place flamingos on a balance board to measure their movements and generated some adorable YouTube footage of baby flamingos as a byproduct. —Lynde Langdon

Twinkle, twinkle mysterious star

Astronomers cannot figure out why Tabby’s Star, a yellow-white dwarf in the constellation Cygnus, randomly goes dim by as much as 22 percent. When the star started to flicker again last week, sky-gazers raised the alarm on social media to get their colleagues to gather as much data as possible. “#TabbysStar IS DIPPING! OBSERVE!!” tweeted Tabetha Boyejian, the researcher for whom the star is nicknamed. She has proposed several interesting but incomplete theories for why the star twinkles randomly. The dimming effect is too extreme to attribute to a passing planet, nor would a cluster of comets block its light in just the right way. One scientist thinks it’s aliens, though he’s pretty well alone in his belief. Over the next few weeks, astronomers will be compiling and analyzing all of the data from Tabby’s most recent dip and maybe come up with some new answers. —L.L.

Another day at the office

On Mother’s Day, the comic strip Dilbert took a stand against climate change pseudo-science. Many global warming apostles didn’t think it was funny and took to Twitter to vent their rage. —L.L.


Kiley Crossland Kiley is a former WORLD correspondent.


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